Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50125908
Substrate
n/a
Meas. Tech.
ChEMBL_30421 (CHEMBL645975)
Ki
81±n/a nM
Citation
 Baraldi, PG; Fruttarolo, F; Tabrizi, MA; Preti, D; Romagnoli, R; El-Kashef, H; Moorman, A; Varani, K; Gessi, S; Merighi, S; Borea, PA Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists. J Med Chem 46:1229-41 (2003) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50125908
Synonyms:
CHEMBL20888 | CHEMBL544678 | N*9*-Ethyl-2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine-5,9-diamine
Type:
Small organic molecule
Emp. Form.:
C13H14N8O
Mol. Mass.:
298.3033
SMILES:
CCNc1n(C)nc2nc(N)n3nc(nc3c12)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: