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Target
Adenosine receptor A1
Ligand
BDBM50149373
Substrate
n/a
Meas. Tech.
ChEMBL_29111 (CHEMBL638723)
Ki
8.7±n/a nM
Citation
 Colotta, V; Catarzi, D; Varano, F; Calabri, FR; Lenzi, O; Filacchioni, G; Martini, C; Trincavelli, L; Deflorian, F; Moro, S 1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies. J Med Chem 47:3580-90 (2004) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_BOVIN | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | ADORA1 | Adenosine A1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36602.99
Organism:
BOVINE
Description:
ADENOSINE 0 BOVINE::P28190
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPRTYFHTCLKVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTPRRAVVAITGCWILSFVVGLTPMFGWNNLSAVERDWLANGSVGEPVIECQFEKVISMEYMVYFNFFVWVLPPLLLMVLIYMEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPVDEDAPAERPDD
  
Inhibitor
Name:
BDBM50149373
Synonyms:
2-(4-Amino-phenyl)-2H,5H-[1,2,4]triazolo[4,3-a]quinoxaline-1,4-dione | CHEMBL118679
Type:
Small organic molecule
Emp. Form.:
C15H11N5O2
Mol. Mass.:
293.2801
SMILES:
Nc1ccc(cc1)-n1nc2n(c3ccccc3[nH]c2=O)c1=O
Structure:
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