Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50144942
Substrate
n/a
Meas. Tech.
ChEMBL_84043 (CHEMBL691889)
IC50
130±n/a nM
Citation
Eldrup, AB; Allerson, CR; Bennett, CF; Bera, S; Bhat, B; Bhat, N; Bosserman, MR; Brooks, J; Burlein, C; Carroll, SS; Cook, PD; Getty, KL; MacCoss, M; McMasters, DR; Olsen, DB; Prakash, TP; Prhavc, M; Song, Q; Tomassini, JE; Xia, J Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem 47:2283-95 (2004) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50144942
Synonyms:
2'-C-Me-guanosine | 2'-C-methyl-guanosine | 2'-C-methylguanosine | 2'-beta-methylguanosine | 2-amino-9-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-1H-purin-6(9H)-one | CHEMBL418899 | beta-2'-Methylguanosine
Type:
Small organic molecule
Emp. Form.:
C11H15N5O5
Mol. Mass.:
297.2673
SMILES:
C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c1nc(N)[nH]c2=O