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Target
RNA-directed RNA polymerase
Ligand
BDBM50422565
Substrate
n/a
Meas. Tech.
ChEMBL_84042 (CHEMBL691888)
EC50
>50000±n/a nM
Citation
 Eldrup, AB; Allerson, CR; Bennett, CF; Bera, S; Bhat, B; Bhat, N; Bosserman, MR; Brooks, J; Burlein, C; Carroll, SS; Cook, PD; Getty, KL; MacCoss, M; McMasters, DR; Olsen, DB; Prakash, TP; Prhavc, M; Song, Q; Tomassini, JE; Xia, J Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem 47:2283-95 (2004) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50422565
Synonyms:
CHEMBL2311161
Type:
Small organic molecule
Emp. Form.:
C11H15N5O4
Mol. Mass.:
281.2679
SMILES:
C[C@]1(O)[C@@H](CO)O[C@H]([C@@H]1O)n1cnc2c(N)ncnc12
Structure:
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