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Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50150875
Substrate
n/a
Meas. Tech.
ChEMBL_302969 (CHEMBL827949)
Ki
23200±n/a nM
Citation
 Fernández, D; Wenck, MA; Craig, SP; Delfino, JM The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds. Bioorg Med Chem Lett 14:4501-4 (2004) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HPRT_TRYBB
Type:
PROTEIN
Mol. Mass.:
23360.10
Organism:
Trypanosoma brucei brucei
Description:
ChEMBL_302489
Residue:
210
Sequence:
MEPACKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVIVSVLKGSFVFTADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILKPSVYETWGKELERRKAAGEAKR
  
Inhibitor
Name:
BDBM50150875
Synonyms:
hydrogen 2-(1,2-dihydropyridin-3-yl)-1-hydroxy-1-(hydroxyphosphinato)ethylphosphonate
Type:
Small organic molecule
Emp. Form.:
C7H11NO7P2
Mol. Mass.:
283.1134
SMILES:
OC(CC1=CCC=NC1)(P(O)([O-])=O)P(O)([O-])=O |c:6,t:3|
Structure:
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