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Target
MO15-related protein kinase Pfmrk
Ligand
BDBM7266
Substrate
n/a
Meas. Tech.
ChEMBL_306159 (CHEMBL832347)
IC50
15000±n/a nM
Citation
 Bhattacharjee, AK; Geyer, JA; Woodard, CL; Kathcart, AK; Nichols, DA; Prigge, ST; Li, Z; Mott, BT; Waters, NC A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. J Med Chem 47:5418-26 (2004) [PubMed]  Article 
Target
Name:
MO15-related protein kinase Pfmrk
Synonyms:
Protein kinase Pfmrk
Type:
PROTEIN
Mol. Mass.:
37992.30
Organism:
Plasmodium falciparum
Description:
ChEMBL_640752
Residue:
324
Sequence:
MENNSTERYIFKPNFLGEGSYGKVYKAYDTILKKEVAIKKMKLNEISNYIDDCGINFVLLREIKIMKEIKHKNIMSALDLYCEKDYINLVMEIMDYDLSKIINRKIFLTDSQKKCILLQILNGLNVLHKYYFMHRDLSPANIFINKKGEVKLADFGLCTKYGYDMYSDKLFRDKYKKNLNLTSKVVTLWYRAPELLLGSNKYNSSIDMWSFGCIFAELLLQKALFPGENEIDQLGKIFFLLGTPNENNWPEALCLPLYTEFTKATKKDFKTYFKIDDDDCIDLLTSFLKLNAHERISAEDAMKHRYFFNDPLPCDISQLPFNDL
  
Inhibitor
Name:
BDBM7266
Synonyms:
14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one | 9-bromopaullone | CHEMBL296586 | Kenpaullone | NSC 664704 | Paullone Analog 5 | cid_3820
Type:
Small organic molecule
Emp. Form.:
C16H11BrN2O
Mol. Mass.:
327.175
SMILES:
Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Structure:
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