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Target
Type-2 angiotensin II receptor
Ligand
BDBM50156167
Substrate
n/a
Meas. Tech.
ChEMBL_303611 (CHEMBL829700)
Ki
0.5±n/a nM
Citation
 Wan, Y; Wallinder, C; Plouffe, B; Beaudry, H; Mahalingam, AK; Wu, X; Johansson, B; Holm, M; Botoros, M; Karlén, A; Pettersson, A; Nyberg, F; Fändriks, L; Gallo-Payet, N; Hallberg, A; Alterman, M Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem 47:5995-6008 (2004) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50156167
Synonyms:
CHEMBL361927 | butyl (5-isobutylthien-2-yl)sulfonylcarbamate derivative
Type:
Small organic molecule
Emp. Form.:
C24H31N3O4S2
Mol. Mass.:
489.651
SMILES:
CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2C)cc1
Structure:
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