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Target
Cytochrome P450 2E1
Ligand
BDBM50158921
Substrate
n/a
Meas. Tech.
ChEMBL_305743 (CHEMBL829415)
IC50
>400000±n/a nM
Citation
 Denton, TT; Zhang, X; Cashman, JR 5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6. J Med Chem 48:224-39 (2005) [PubMed]  Article 
Target
Name:
Cytochrome P450 2E1
Synonyms:
CP2E1_HUMAN | CYP2E | CYP2E1 | Cytochrome P450 2E1 (CYP2E1)
Type:
Enzyme
Mol. Mass.:
56860.34
Organism:
Homo sapiens (Human)
Description:
P05181
Residue:
493
Sequence:
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS
  
Inhibitor
Name:
BDBM50158921
Synonyms:
5-Pyridin-3-yl-furan-2-carbaldehyde oxime | 5-Pyridin-3-yl-furan-2-carbaldehyde oxime; compound with 5-pyridin-3-yl-furan-2-carbaldehyde oxime | CHEMBL178330 | CHEMBL178547 | CHEMBL1795039 | US8609708, 24 | US8609708, 39 | US8609708, 72
Type:
Small organic molecule
Emp. Form.:
C10H8N2O2
Mol. Mass.:
188.1827
SMILES:
O=NCc1ccc(o1)-c1cccnc1
Structure:
Search PDB for entries with ligand similarity: