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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50080017
Substrate
n/a
Meas. Tech.
ChEMBL_303441 (CHEMBL839610)
Ki
2±n/a nM
Citation
 Laggner, C; Schieferer, C; Fiechtner, B; Poles, G; Hoffmann, RD; Glossmann, H; Langer, T; Moebius, FF Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. J Med Chem 48:4754-64 (2005) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50080017
Synonyms:
(+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol] | (+/-)-ifenprodil | -(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phenol | 4-((1S,2R)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phenol | 4-(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phenol | 4-[(1S,2R)-2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol | 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol | CHEMBL113830 | ifenprodil
Type:
Small organic molecule
Emp. Form.:
C21H27NO2
Mol. Mass.:
325.4446
SMILES:
C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r|
Structure:
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