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Target
cGMP-gated cation channel alpha-1
Ligand
BDBM50172536
Substrate
n/a
Meas. Tech.
ChEMBL_320711 (CHEMBL881697)
Kd
3100±n/a nM
Citation
 Strassmaier, T; Uma, R; Ghatpande, AS; Bandyopadhyay, T; Schaffer, M; Witte, J; McDougal, PG; Brown, RL; Karpen, JW Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies. J Med Chem 48:5805-12 (2005) [PubMed]  Article 
Target
Name:
cGMP-gated cation channel alpha-1
Synonyms:
CNCG | CNCG1 | CNGA1 | CNGA1_BOVIN | cGMP-gated cation channel alpha 1
Type:
PROTEIN
Mol. Mass.:
79603.33
Organism:
Bos taurus
Description:
ChEMBL_320711
Residue:
690
Sequence:
MKKVIINTWHSFVNIPNVVGPDVEKEITRMENGACSSFSGDDDDSASMFEESETENPHARDSFRSNTHGSGQPSQREQYLPGAIALFNVNNSSNKEQEPKEKKKKKKEKKSKPDDKNENKKDPEKKKKKEKDKDKKKKEEKGKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMIIARACFDELQSDYLEYWLAFDYLSDVVYLLDMFVRTRTGYLEQGLLVKEERKLIDKYKSTFQFKLDVLSVIPTDLLYIKFGWNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRISNLVMYIIIIIHWNACVYFSISKAIGFGNDTWVYPDVNDPDFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYFFVVADFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKGMLEEKGKQILMKDGLLDINIANAGSDPKDLEEKVTRMESSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSAIEGSGTESGPTDSTQD
  
Inhibitor
Name:
BDBM50172536
Synonyms:
Butyl-[2-(4-butylamino-benzoyloxy)-ethyl]-dimethyl-ammonium | CHEMBL195005
Type:
Small organic molecule
Emp. Form.:
C19H33N2O2
Mol. Mass.:
321.477
SMILES:
CCCCNc1ccc(cc1)C(=O)OCC[N+](C)(C)CCCC
Structure:
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