Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Ligand
BDBM50173546
Substrate
n/a
Meas. Tech.
ChEMBL_320965 (CHEMBL885372)
Ki
1900±n/a nM
Citation
 Nguyen, C; Kasinathan, G; Leal-Cortijo, I; Musso-Buendia, A; Kaiser, M; Brun, R; Ruiz-Pérez, LM; Johansson, NG; González-Pacanowska, D; Gilbert, IH Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target. J Med Chem 48:5942-54 (2005) [PubMed]  Article 
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Synonyms:
dUTP pyrophosphatase
Type:
Protein
Mol. Mass.:
19574.43
Organism:
Plasmodium falciparum
Description:
Q8II92
Residue:
173
Sequence:
MHLKIVCLSDEVREMYKNHKTHHEGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKSNYYYKCEKSENKKKDDDKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAALDNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGSTSNNKY
  
Inhibitor
Name:
BDBM50173546
Synonyms:
1-(5-Trityloxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione | CHEMBL369937 | dUTPase inhibitor, 2
Type:
Small organic molecule
Emp. Form.:
C28H24N2O4
Mol. Mass.:
452.5012
SMILES:
O=c1ccn(C2OC(COC(c3ccccc3)(c3ccccc3)c3ccccc3)C=C2)c(=O)[nH]1 |c:32|
Structure:
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