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Target
H(+)-exporting diphosphatase
Ligand
BDBM50138048
Substrate
n/a
Meas. Tech.
ChEMBL_321446 (CHEMBL880254)
IC50
2400±n/a nM
Citation
 Kotsikorou, E; Song, Y; Chan, JM; Faelens, S; Tovian, Z; Broderick, E; Bakalara, N; Docampo, R; Oldfield, E Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase. J Med Chem 48:6128-39 (2005) [PubMed]  Article 
Target
Name:
H(+)-exporting diphosphatase
Synonyms:
Vacuolar-type proton translocating pyrophosphatase 1
Type:
PROTEIN
Mol. Mass.:
85914.14
Organism:
Trypanosoma brucei
Description:
ChEMBL_321446
Residue:
826
Sequence:
MIKMSPLLLKAAVVTACLCSLAVATTVEEQTAPKPIENATTYQQELGGRGKVDSPTAPGDAVSITSGIKVMSVTTATAIIFLASAFGFSFAMYWWYVASDIKITPGKGNIMRNAHLTDEVMRNVYVISKRVSDGANAFLFAEYRYMGIFMLGFGALLYFLLGVAMSSPQGEGKDGRPPVAVEAPWVNAAFSLYAFVIGAFTSVLAGWIGMRIAVYTNSRTAVMATVGSGGSDNDVLANGSQSRGYALAFQTAFRGGITMGFALTSIGLFALFCTVKLMQTYFGDSAERLPELFECVAAFGLGGSSVACFGRVGGGIYTKAADVGADLVGKVEKNIPEDDARNPGVIADCIGDNVGDIAGMGSDLFGSFGEATCAALVIAASSAELSADFTCMMYPLLITAGGIFVCIGTALLAATNSGVKWAEDIEPTLKHQLLVSTIGATVVLVFITAYSLPDAFTVGAVETTKWRAMVCVLCGLWSGLLIGYSTEYFTSNSYRPVQEIAESCETGAATNIIYGLSLGYISVLPPILAMAFTIYLSHHCAGLYGYALAALGILSTMSIALTIDAYGPISDNAGGIAEMAHMGHEIREITDALDAAGNTTAAIGKGFAIGSAAFVALALYGAYVSRVGISTVNLLDARVMAGLLLGAMLPYWFSALTMKSVGVAAMDMVNEIRRQFQDPAVAAGTKEPDYESCVNIATGAALQQMVAPACLVMLAPIVTGILFGRYTLAGLLPGALVSGVQVAISASNTGGAWDNAKKYIEKGGLRDKSKGKGSPQHAAAVIGDTVGDPLKDTSGPALNILVKLMAIISVVFAPVVQSKLGGLLVK
  
Inhibitor
Name:
BDBM50138048
Synonyms:
(3-ethylphenylamino)methylenediphosphonic acid | CHEMBL54925 | [(3-Ethyl-phenylamino)-phosphono-methyl]-phosphonic acid | [(3-ethylphenyl)aminomethylene]-1,1-bisphosphonate
Type:
Small organic molecule
Emp. Form.:
C9H15NO6P2
Mol. Mass.:
295.166
SMILES:
CCc1cccc(NC(P(O)(O)=O)P(O)(O)=O)c1
Structure:
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