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Target
H(+)-exporting diphosphatase
Ligand
BDBM50173774
Substrate
n/a
Meas. Tech.
ChEMBL_321446 (CHEMBL880254)
IC50
48000±n/a nM
Citation
 Kotsikorou, E; Song, Y; Chan, JM; Faelens, S; Tovian, Z; Broderick, E; Bakalara, N; Docampo, R; Oldfield, E Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase. J Med Chem 48:6128-39 (2005) [PubMed]  Article 
Target
Name:
H(+)-exporting diphosphatase
Synonyms:
Vacuolar-type proton translocating pyrophosphatase 1
Type:
PROTEIN
Mol. Mass.:
85914.14
Organism:
Trypanosoma brucei
Description:
ChEMBL_321446
Residue:
826
Sequence:
MIKMSPLLLKAAVVTACLCSLAVATTVEEQTAPKPIENATTYQQELGGRGKVDSPTAPGDAVSITSGIKVMSVTTATAIIFLASAFGFSFAMYWWYVASDIKITPGKGNIMRNAHLTDEVMRNVYVISKRVSDGANAFLFAEYRYMGIFMLGFGALLYFLLGVAMSSPQGEGKDGRPPVAVEAPWVNAAFSLYAFVIGAFTSVLAGWIGMRIAVYTNSRTAVMATVGSGGSDNDVLANGSQSRGYALAFQTAFRGGITMGFALTSIGLFALFCTVKLMQTYFGDSAERLPELFECVAAFGLGGSSVACFGRVGGGIYTKAADVGADLVGKVEKNIPEDDARNPGVIADCIGDNVGDIAGMGSDLFGSFGEATCAALVIAASSAELSADFTCMMYPLLITAGGIFVCIGTALLAATNSGVKWAEDIEPTLKHQLLVSTIGATVVLVFITAYSLPDAFTVGAVETTKWRAMVCVLCGLWSGLLIGYSTEYFTSNSYRPVQEIAESCETGAATNIIYGLSLGYISVLPPILAMAFTIYLSHHCAGLYGYALAALGILSTMSIALTIDAYGPISDNAGGIAEMAHMGHEIREITDALDAAGNTTAAIGKGFAIGSAAFVALALYGAYVSRVGISTVNLLDARVMAGLLLGAMLPYWFSALTMKSVGVAAMDMVNEIRRQFQDPAVAAGTKEPDYESCVNIATGAALQQMVAPACLVMLAPIVTGILFGRYTLAGLLPGALVSGVQVAISASNTGGAWDNAKKYIEKGGLRDKSKGKGSPQHAAAVIGDTVGDPLKDTSGPALNILVKLMAIISVVFAPVVQSKLGGLLVK
  
Inhibitor
Name:
BDBM50173774
Synonyms:
CHEMBL371673 | [2-(Adamantan-1-ylamino)-1-phosphono-ethyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C12H23NO6P2
Mol. Mass.:
339.2616
SMILES:
OP(O)(=O)C(CNC12CC3CC(CC(C3)C1)C2)P(O)(O)=O |TLB:10:11:15:9.8.14,THB:10:9:15:11.16.12,12:11:8:13.15.14,12:13:8:11.16.10|
Structure:
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