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Target
High affinity choline transporter 1
Ligand
BDBM85206
Substrate
n/a
Meas. Tech.
ChEMBL_321555 (CHEMBL881969)
IC50
12±n/a nM
Citation
 Minetti, P; Tinti, MO; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Piersanti, G; Bartoccini, F; Tarzia, G 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. J Med Chem 48:6887-96 (2005) [PubMed]  Article 
Target
Name:
High affinity choline transporter 1
Synonyms:
CHT | Cht1 | Hemicholinium-3-sensitive choline transporter | SC5A7_RAT | Slc5a7 | Solute carrier family 5 member 7
Type:
PROTEIN
Mol. Mass.:
63400.14
Organism:
Rattus norvegicus
Description:
ChEMBL_644788
Residue:
580
Sequence:
MPFHVEGLVAIILFYLLIFLVGIWAAWKTKNSGNAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIGFTAVHAKYQSPWLGTIESVEVYTWLDNFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTDWNQTAYGFPDPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITGGEPYLYLQPLIFYPGYYPDKNGIYNQRFPFKTLSMVTSFFTNICVSYLAKYLFESGTLPPKLDIFDAVVSRHSEENMDKTILVRNENIKLNELAPVKPRQSLTLSSTFTNKEALLDVDSSPEGSGTEDNLQ
  
Inhibitor
Name:
BDBM85206
Synonyms:
CAS_312-45-8 | Hemicholinium-3 | NSC_9399
Type:
Small organic molecule
Emp. Form.:
C24H34N2O4
Mol. Mass.:
414.5367
SMILES:
C[N+]1(C)CCOC(O)(C1)c1ccc(cc1)-c1ccc(cc1)C1(O)C[N+](C)(C)CCO1
Structure:
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