Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM50174317
Substrate
n/a
Meas. Tech.
ChEMBL_326055 (CHEMBL864544)
IC50
650±n/a nM
Citation
Lescop, C; Herzner, H; Siendt, H; Bolliger, R; Henneböhle, M; Weyermann, P; Briguet, A; Courdier-Fruh, I; Erb, M; Foster, M; Meier, T; Magyar, JP; von Sprecher, A Novel cell-penetrating alpha-keto-amide calpain inhibitors as potential treatment for muscular dystrophy. Bioorg Med Chem Lett 15:5176-81 (2005) [PubMed] Article
More Info.:
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Inhibitor
Name:
BDBM50174317
Synonyms:
(S)-2-(5-[1,2]dithiolan-3-yl-pentanoylamino)-4-methyl-pentanoic acid [1-(4-bromo-benzyl)-2-ethylcarbamoyl-2-oxo-ethyl]-amide | CHEMBL200826
Type:
Small organic molecule
Emp. Form.:
C26H38BrN3O4S2
Mol. Mass.:
600.632
SMILES:
CCNC(=O)C(=O)C(Cc1ccc(Br)cc1)NC(=O)[C@H](CC(C)C)NC(=O)CCCCC1CCSS1