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Target
D(4) dopamine receptor
Ligand
BDBM50180913
Substrate
n/a
Meas. Tech.
ChEMBL_327100 (CHEMBL859836)
Ki
11.3±n/a nM
Citation
Hoefgen, B; Decker, M; Mohr, P; Schramm, AM; Rostom, SA; El-Subbagh, H; Schweikert, PM; Rudolf, DR; Kassack, MU; Lehmann, J Dopamine/serotonin receptor ligands. 10: SAR Studies on azecine-type dopamine receptor ligands by functional screening at human cloned D1, D2L, and D5 receptors with a microplate reader based calcium assay lead to a novel potent D1/D5 selective antagonist. J Med Chem 49:760-9 (2006) [PubMed] Article
More Info.:
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
Inhibitor
Name:
BDBM50180913
Synonyms:
11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(18),3(8),4,6,14,16-hexaen-6-ol | 11-methyl-11-aza-tricyclo[12.4.0.03,8]octadeca-1(14),3,5,7,15,17-hexaen-6-ol | 3-hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine | 7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-ol | CHEMBL1204122 | CHEMBL201170 | LE404
Type:
Small organic molecule
Emp. Form.:
C18H21NO
Mol. Mass.:
267.3654
SMILES:
CN1CCc2ccccc2Cc2ccc(O)cc2CC1