Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50187329
Substrate
n/a
Meas. Tech.
ChEMBL_357594 (CHEMBL871314)
EC50
5±n/a nM
Citation
 Pedretti, A; Villa, M; Pallavicini, M; Valoti, E; Vistoli, G Construction of human ghrelin receptor (hGHS-R1a) model using a fragmental prediction approach and validation through docking analysis. J Med Chem 49:3077-85 (2006) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50187329
Synonyms:
(R,E)-6-((1-((2-(2-hydroxyethoxy)phenethyl)(methyl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)(methyl)amino)-2-methyl-6-oxohex-4-en-2-aminium | 5-amino-5-methyl-hex-2-enoic acid [(R)-1-({2-[2-(2-hydroxy-ethoxy)-phenyl]-ethyl}-methyl-carbamoyl)-2-naphthalen-2-yl-ethyl]-methyl-amide | CHEMBL441360
Type:
Small organic molecule
Emp. Form.:
C32H41N3O4
Mol. Mass.:
531.6856
SMILES:
CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)\C=C\CC(C)(C)N
Structure:
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