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Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50187337
Substrate
n/a
Meas. Tech.
ChEMBL_357594 (CHEMBL871314)
EC50
2±n/a nM
Citation
 Pedretti, A; Villa, M; Pallavicini, M; Valoti, E; Vistoli, G Construction of human ghrelin receptor (hGHS-R1a) model using a fragmental prediction approach and validation through docking analysis. J Med Chem 49:3077-85 (2006) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50187337
Synonyms:
1-((R)-1-{2'-[3-(2-hydroxy-ethyl)-ureidomethyl]-biphenyl-4-ylmethyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-1-methyl-ethyl-ammonium | 2-amino-N-((R)-1-{2'-[3-(2-hydroxy-ethyl)-ureidomethyl]-biphenyl-4-ylmethyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-2-methyl-propionamide | CHEMBL295984
Type:
Small organic molecule
Emp. Form.:
C31H37N5O4
Mol. Mass.:
543.6566
SMILES:
CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(cc2)-c2ccccc2CNC(=O)NCCO)C1=O
Structure:
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