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Target
P-selectin glycoprotein ligand 1
Ligand
BDBM50324667
Substrate
n/a
Meas. Tech.
ChEMBL_423294 (CHEMBL855465)
IC50
70000±n/a nM
Citation
 Kaila, N; Janz, K; DeBernardo, S; Bedard, PW; Camphausen, RT; Tam, S; Tsao, DH; Keith, JC; Nickerson-Nutter, C; Shilling, A; Young-Sciame, R; Wang, Q Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J Med Chem 50:21-39 (2007) [PubMed]  Article 
Target
Name:
P-selectin glycoprotein ligand 1
Synonyms:
P-selectin glycoprotein ligand 1 | P-selectin/P-selectin glycoprotein ligand 1 | SELPLG | SELPL_HUMAN
Type:
PROTEIN
Mol. Mass.:
43174.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_649756
Residue:
412
Sequence:
MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPPEMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAASNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPTEMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP
  
Inhibitor
Name:
BDBM50324667
Synonyms:
1,6-bis[3-(3-carboxymethylphenyl)-4-(2-R-D-mannopyranosyloxy)phenyl]hexane | CHEMBL1215923 | TBC-1269
Type:
Small organic molecule
Emp. Form.:
C46H54O16
Mol. Mass.:
862.9114
SMILES:
OC[C@H]1O[C@H](Oc2ccc(CCCCCCc3ccc(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)c(c3)-c3cccc(CC(O)=O)c3)cc2-c2cccc(CC(O)=O)c2)[C@@H](O)[C@@H](O)[C@@H]1O |r|
Structure:
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