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Target
P-selectin glycoprotein ligand 1
Ligand
BDBM50201931
Substrate
n/a
Meas. Tech.
ChEMBL_423294 (CHEMBL855465)
IC50
125000±n/a nM
Citation
 Kaila, N; Janz, K; DeBernardo, S; Bedard, PW; Camphausen, RT; Tam, S; Tsao, DH; Keith, JC; Nickerson-Nutter, C; Shilling, A; Young-Sciame, R; Wang, Q Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J Med Chem 50:21-39 (2007) [PubMed]  Article 
Target
Name:
P-selectin glycoprotein ligand 1
Synonyms:
P-selectin glycoprotein ligand 1 | P-selectin/P-selectin glycoprotein ligand 1 | SELPLG | SELPL_HUMAN
Type:
PROTEIN
Mol. Mass.:
43174.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_649756
Residue:
412
Sequence:
MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPPEMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAASNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPTEMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP
  
Inhibitor
Name:
BDBM50201931
Synonyms:
6-bromo-2-(4-chlorophenyl)-3-hydroxy-8-methylquinoline-4-carboxylic acid | CHEMBL218051
Type:
Small organic molecule
Emp. Form.:
C17H11BrClNO3
Mol. Mass.:
392.631
SMILES:
Cc1cc(Br)cc2c(C(O)=O)c(O)c(nc12)-c1ccc(Cl)cc1
Structure:
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