Target
Cytochrome P450 2C8
Ligand
BDBM50201901
Substrate
n/a
Meas. Tech.
ChEMBL_423306 (CHEMBL908900)
IC50
4800±n/a nM
Citation
 Kaila, NJanz, KDeBernardo, SBedard, PWCamphausen, RTTam, STsao, DHKeith, JCNickerson-Nutter, CShilling, AYoung-Sciame, RWang, Q Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J Med Chem 50:21-39 (2007) [PubMed]  Article 
Target
Name:
Cytochrome P450 2C8
Synonyms:
CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase
Type:
Protein
Mol. Mass.:
55839.23
Organism:
Homo sapiens (Human)
Description:
P10632
Residue:
490
Sequence:
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV
  
Inhibitor
Name:
BDBM50201901
Synonyms:
2-(4-chlorophenyl)-3-hydroxy-8-phenylquinoline-4-carboxylicacid | CHEMBL218583
Type:
Small organic molecule
Emp. Form.:
C22H14ClNO3
Mol. Mass.:
375.804
SMILES:
OC(=O)c1c(O)c(nc2c(cccc12)-c1ccccc1)-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: