Reaction Details Report a problem with these data
Target
Protein arginine N-methyltransferase 1 [11-371]
Ligand
BDBM50206440
Substrate
n/a
Meas. Tech.
ChEMBL_428527 (CHEMBL919884)
IC50
>34000±n/a nM
Citation
Ragno, R; Simeoni, S; Castellano, S; Vicidomini, C; Mai, A; Caroli, A; Tramontano, A; Bonaccini, C; Trojer, P; Bauer, I; Brosch, G; Sbardella, G Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations. J Med Chem 50:1241-53 (2007) [PubMed] Article
More Info.:
Target
Name:
Protein arginine N-methyltransferase 1 [11-371]
Synonyms:
ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1
Type:
Protein
Mol. Mass.:
41506.52
Organism:
Homo sapiens (Human)
Description:
Q99873[11-371]
Residue:
361
Sequence:
MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
Inhibitor
Name:
BDBM50206440
Synonyms:
({3-[1-{3-[(bis-carboxymethyl-amino-methyl]-4-hydroxy-5-isopropyl-2-methyl-phenyl}-1-(2-sulfo-phenyl)-meth-(E)-ylidene]-5-isopropyl-2-methyl-6-oxo-cyclohexa-1,4-dienylmethyl}-carboxymethyl-amino)-acetic acid | CHEMBL374644
Type:
Small organic molecule
Emp. Form.:
C37H44N2O13S
Mol. Mass.:
756.816
SMILES:
CC(C)c1cc(C(c2ccccc2S(O)(=O)=O)=c2cc(C(C)C)c(O)c(CN(CC(O)=O)CC(O)=O)c2=C)c(C)c(CN(CC(O)=O)CC(O)=O)c1O |w:6.5|