Reaction Details Report a problem with these data
Target
RmtA
Ligand
BDBM50206440
Substrate
n/a
Meas. Tech.
ChEMBL_428528 (CHEMBL919885)
IC50
>34000±n/a nM
Citation
Ragno, R; Simeoni, S; Castellano, S; Vicidomini, C; Mai, A; Caroli, A; Tramontano, A; Bonaccini, C; Trojer, P; Bauer, I; Brosch, G; Sbardella, G Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations. J Med Chem 50:1241-53 (2007) [PubMed] Article
More Info.:
Target
Name:
RmtA
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
39351.26
Organism:
Emericella nidulans
Description:
ChEMBL_475539
Residue:
345
Sequence:
MSEIENSTITSSADRMVGMDHAEVRYFTSYDHHGIHEEMLKDDVRTRSYRDSIYQNRHIFKDKVVLDVGCGTGILSMFAAKAGAKHVIGVDMSSIIEKAREIVAVNGLADKITLLQGKMEEVQLPFPSVDIIISEWMGYFLLYESMLDTVLYAQDRYLVPGGKIFPDKATMYLAGIEDGEYKDDKIGFWDNVYGFDYSPMKEIALTEPLVDTVELKALVTDPCPIITFDLYTVTKEDLAFEVPYSLPVKRSDFVHAVIAWFDIEFGACHKPINFSTGPHAKYTHWKQTVFYLRDVLTVEEEESISGVLSNRPNDKNKRDLDINLTYKLETQDQTRFAEGGCFYRM
Inhibitor
Name:
BDBM50206440
Synonyms:
({3-[1-{3-[(bis-carboxymethyl-amino-methyl]-4-hydroxy-5-isopropyl-2-methyl-phenyl}-1-(2-sulfo-phenyl)-meth-(E)-ylidene]-5-isopropyl-2-methyl-6-oxo-cyclohexa-1,4-dienylmethyl}-carboxymethyl-amino)-acetic acid | CHEMBL374644
Type:
Small organic molecule
Emp. Form.:
C37H44N2O13S
Mol. Mass.:
756.816
SMILES:
CC(C)c1cc(C(c2ccccc2S(O)(=O)=O)=c2cc(C(C)C)c(O)c(CN(CC(O)=O)CC(O)=O)c2=C)c(C)c(CN(CC(O)=O)CC(O)=O)c1O |w:6.5|