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Target
RmtA
Ligand
BDBM50206432
Substrate
n/a
Meas. Tech.
ChEMBL_428528 (CHEMBL919885)
IC50
73000±n/a nM
Citation
 Ragno, R; Simeoni, S; Castellano, S; Vicidomini, C; Mai, A; Caroli, A; Tramontano, A; Bonaccini, C; Trojer, P; Bauer, I; Brosch, G; Sbardella, G Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations. J Med Chem 50:1241-53 (2007) [PubMed]  Article 
Target
Name:
RmtA
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
39351.26
Organism:
Emericella nidulans
Description:
ChEMBL_475539
Residue:
345
Sequence:
MSEIENSTITSSADRMVGMDHAEVRYFTSYDHHGIHEEMLKDDVRTRSYRDSIYQNRHIFKDKVVLDVGCGTGILSMFAAKAGAKHVIGVDMSSIIEKAREIVAVNGLADKITLLQGKMEEVQLPFPSVDIIISEWMGYFLLYESMLDTVLYAQDRYLVPGGKIFPDKATMYLAGIEDGEYKDDKIGFWDNVYGFDYSPMKEIALTEPLVDTVELKALVTDPCPIITFDLYTVTKEDLAFEVPYSLPVKRSDFVHAVIAWFDIEFGACHKPINFSTGPHAKYTHWKQTVFYLRDVLTVEEEESISGVLSNRPNDKNKRDLDINLTYKLETQDQTRFAEGGCFYRM
  
Inhibitor
Name:
BDBM50206432
Synonyms:
4-(4,6-dichloro-1,3,5-triazin-2-ylamino)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid | CHEMBL222509
Type:
Small organic molecule
Emp. Form.:
C23H12Cl2N4O5
Mol. Mass.:
495.271
SMILES:
OC(=O)c1ccc(Nc2nc(Cl)nc(Cl)n2)cc1-c1c2ccc(O)cc2oc2cc(=O)ccc12 |(23.23,-31.33,;23.79,-29.89,;22.82,-28.7,;25.31,-29.65,;25.3,-28.12,;26.63,-27.33,;27.97,-28.1,;29.3,-27.32,;29.29,-25.78,;27.95,-25.03,;27.94,-23.49,;26.6,-22.73,;29.28,-22.71,;30.61,-23.47,;31.94,-22.69,;30.62,-25.01,;27.98,-29.63,;26.64,-30.4,;26.65,-31.94,;27.99,-32.7,;29.32,-31.92,;30.66,-32.68,;30.67,-34.23,;32.01,-34.99,;29.34,-35.01,;28,-34.25,;26.66,-35.02,;25.33,-34.26,;23.99,-35.04,;22.66,-34.27,;21.33,-35.03,;22.66,-32.72,;23.99,-31.95,;25.33,-32.71,)|
Structure:
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