Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50176889
Substrate
n/a
Meas. Tech.
ChEMBL_430868 (CHEMBL913938)
Kd
4400±n/a nM
Citation
Wu, Q; Gee, CL; Lin, F; Tyndall, JD; Martin, JL; Grunewald, GL; McLeish, MJ Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase. J Med Chem 48:7243-52 (2005) [PubMed] Article
More Info.:
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:
Enzyme
Mol. Mass.:
30852.66
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
Inhibitor
Name:
BDBM50176889
Synonyms:
6-Trifluoromethyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-9-ylamine | CHEMBL289520 | anti-9-amino-6-(trifluoromethyl)benzonorbornene
Type:
Small organic molecule
Emp. Form.:
C12H12F3N
Mol. Mass.:
227.2256
SMILES:
NC1C2CCC1c1cc(ccc21)C(F)(F)F |TLB:7:6:1:4.3,0:1:6.11:4.3|