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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50177109
Substrate
n/a
Meas. Tech.
ChEMBL_431030 (CHEMBL915900)
IC50
1100±n/a nM
Citation
 Kotturi, SV; Jiang, S; Chang, AC; Abraham, P; Navarro, HA; Kuhar, MJ; Carroll, FI Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes. J Med Chem 48:7437-44 (2005) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50177109
Synonyms:
(R)-3-alpha-(methylphenyl)-2-alpha-phenyltropane | (R)-3beta-(methylphenyl)-2-beta-phenyltropane | CHEMBL224771
Type:
Small organic molecule
Emp. Form.:
C21H25N
Mol. Mass.:
291.4299
SMILES:
CN1C2CCC1[C@H]([C@H](C2)c1ccc(C)cc1)c1ccccc1 |r,TLB:16:6:4.3:1,THB:9:7:4.3:1|
Structure:
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