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Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50213094
Substrate
n/a
Meas. Tech.
ChEMBL_436809 (CHEMBL905111)
IC50
3600±n/a nM
Citation
 Plouvier, B; Beatch, GN; Jung, GL; Zolotoy, A; Sheng, T; Clohs, L; Barrett, TD; Fedida, D; Wang, WQ; Zhu, JJ; Liu, Y; Abraham, S; Lynn, L; Dong, Y; Wall, RA; Walker, MJ Synthesis and biological studies of novel 2-aminoalkylethers as potential antiarrhythmic agents for the conversion of atrial fibrillation. J Med Chem 50:2818-41 (2007) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50213094
Synonyms:
(1R,2R)-1-(3,4-dichlorophenethoxy)-2-(4-morpholinyl)cyclohexane | CHEMBL387935
Type:
Small organic molecule
Emp. Form.:
C18H25Cl2NO2
Mol. Mass.:
358.303
SMILES:
Clc1ccc(CCO[C@@H]2CCCC[C@H]2N2CCOCC2)cc1Cl
Structure:
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