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Target
Potassium voltage-gated channel subfamily D member 2
Ligand
BDBM50213093
Substrate
n/a
Meas. Tech.
ChEMBL_436810 (CHEMBL905112)
IC50
11000±n/a nM
Citation
 Plouvier, B; Beatch, GN; Jung, GL; Zolotoy, A; Sheng, T; Clohs, L; Barrett, TD; Fedida, D; Wang, WQ; Zhu, JJ; Liu, Y; Abraham, S; Lynn, L; Dong, Y; Wall, RA; Walker, MJ Synthesis and biological studies of novel 2-aminoalkylethers as potential antiarrhythmic agents for the conversion of atrial fibrillation. J Med Chem 50:2818-41 (2007) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily D member 2
Synonyms:
KCND2_RAT | Kcnd2 | RK5 | Shal1 | Voltage-gated potassium channel subunit Kv4.2
Type:
PROTEIN
Mol. Mass.:
70560.86
Organism:
Rattus norvegicus
Description:
ChEMBL_436810
Residue:
630
Sequence:
MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDNTGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEPAFVSKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKSFRIPNANVSGSHRGSVQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIPTPPVTTPEGDDRPESPEYSGGNIVRVSAL
  
Inhibitor
Name:
BDBM50213093
Synonyms:
(1R,2R)-1-(1-naphthalenethoxy)-2-(3-ketopyrrolidinyl)cyclohexane | CHEMBL229125
Type:
Small organic molecule
Emp. Form.:
C22H27NO2
Mol. Mass.:
337.4553
SMILES:
O=C1CCN(C1)[C@@H]1CCCC[C@H]1OCCc1cccc2ccccc12
Structure:
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