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Target
Isocitrate lyase
Ligand
BDBM50370994
Substrate
n/a
Meas. Tech.
ChEMBL_438441 (CHEMBL886419)
IC50
67400±n/a nM
Citation
 Lee, HS; Lee, TH; Yang, SH; Shin, HJ; Shin, J; Oh, KB Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. Bioorg Med Chem Lett 17:2483-6 (2007) [PubMed]  Article 
Target
Name:
Isocitrate lyase
Synonyms:
ACEA_MAGO7 | ICL | ICL1 | Isocitrase | Isocitratase
Type:
PROTEIN
Mol. Mass.:
61002.51
Organism:
Magnaporthe oryzae (strain 70-15 / FGSC 8958) (Rice blast fungus)(Pyricularia oryzae)
Description:
ChEMBL_438441
Residue:
547
Sequence:
MASKNMVNPAVEPSMEDDLFAREVAEVKQWWSDPRWRYTKRPFTAEQIVSKRGNLKIEYPSNAQSKKLWKILEGRFQKRDASYTYGCLEPTMVTQMAKYLDTVYVSGWQSSSTASSSDEPGPDLADYPYTTVPNKVSHLFMAQLFHDRKQRHERLSAPKSERSKLQNIDYLRPIIADADTGHGGLTAVMKLTKLFIEKGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLVAIRAQADIMGVDLLAIARTDAEAATLITTSIDPRDHAFILGCTNPSLQPLADLMNTAEQSGKTGDQLQAIEDEWMAKANLKRFDDAVVDVINSSSSIRNPKDVAAKYLQAAKGKSNREARAIASSLGVPEIFFDWDSPRTREGYFRIKGGCDCAINRAIAYAPYADAIWMESKLPDYEQAKEFAEGVHAVYPEQKLAYNLSPSFNWKTAMPRDEQETYIRRLAGLGYCWQFITLAGLHTTALISDRFARAYSEVGMRAYGELVQEPEMELGVDVVKHQKWSGATYVDELQKMVTGGVSSTAAMGKGVTEDQFH
  
Inhibitor
Name:
BDBM50370994
Synonyms:
CHEMBL230057
Type:
Small organic molecule
Emp. Form.:
C25H39O5S
Mol. Mass.:
451.64
SMILES:
C[C@@H]1CC[C@@]2(C)[C@H](CCCC2=C)[C@@]1(C)CCC(CCCc1ccoc1)COS([O-])(=O)=O |w:16.17|
Structure:
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