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Target
Isocitrate lyase
Ligand
BDBM50274515
Substrate
n/a
Meas. Tech.
ChEMBL_438441 (CHEMBL886419)
IC50
92400±n/a nM
Citation
 Lee, HS; Lee, TH; Yang, SH; Shin, HJ; Shin, J; Oh, KB Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. Bioorg Med Chem Lett 17:2483-6 (2007) [PubMed]  Article 
Target
Name:
Isocitrate lyase
Synonyms:
ACEA_MAGO7 | ICL | ICL1 | Isocitrase | Isocitratase
Type:
PROTEIN
Mol. Mass.:
61002.51
Organism:
Magnaporthe oryzae (strain 70-15 / FGSC 8958) (Rice blast fungus)(Pyricularia oryzae)
Description:
ChEMBL_438441
Residue:
547
Sequence:
MASKNMVNPAVEPSMEDDLFAREVAEVKQWWSDPRWRYTKRPFTAEQIVSKRGNLKIEYPSNAQSKKLWKILEGRFQKRDASYTYGCLEPTMVTQMAKYLDTVYVSGWQSSSTASSSDEPGPDLADYPYTTVPNKVSHLFMAQLFHDRKQRHERLSAPKSERSKLQNIDYLRPIIADADTGHGGLTAVMKLTKLFIEKGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLVAIRAQADIMGVDLLAIARTDAEAATLITTSIDPRDHAFILGCTNPSLQPLADLMNTAEQSGKTGDQLQAIEDEWMAKANLKRFDDAVVDVINSSSSIRNPKDVAAKYLQAAKGKSNREARAIASSLGVPEIFFDWDSPRTREGYFRIKGGCDCAINRAIAYAPYADAIWMESKLPDYEQAKEFAEGVHAVYPEQKLAYNLSPSFNWKTAMPRDEQETYIRRLAGLGYCWQFITLAGLHTTALISDRFARAYSEVGMRAYGELVQEPEMELGVDVVKHQKWSGATYVDELQKMVTGGVSSTAAMGKGVTEDQFH
  
Inhibitor
Name:
BDBM50274515
Synonyms:
3-nitropropanoic acid | 3-nitropropionic acid | Bovinocidin | CHEMBL231421 | CHEMBL451226
Type:
Small organic molecule
Emp. Form.:
C3H4NO4
Mol. Mass.:
118.0687
SMILES:
[O-]C(=O)CC[N+]([O-])=O
Structure:
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