Reaction Details Report a problem with these data
Target
RmtA
Ligand
BDBM50215479
Substrate
n/a
Meas. Tech.
ChEMBL_439623 (CHEMBL888739)
IC50
46200±n/a nM
Citation
 Spannhoff, A; Machmur, R; Heinke, R; Trojer, P; Bauer, I; Brosch, G; Schüle, R; Hanefeld, W; Sippl, W; Jung, M A novel arginine methyltransferase inhibitor with cellular activity. Bioorg Med Chem Lett 17:4150-3 (2007) [PubMed]  Article 
Target
Name:
RmtA
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
39351.26
Organism:
Emericella nidulans
Description:
ChEMBL_475539
Residue:
345
Sequence:
MSEIENSTITSSADRMVGMDHAEVRYFTSYDHHGIHEEMLKDDVRTRSYRDSIYQNRHIFKDKVVLDVGCGTGILSMFAAKAGAKHVIGVDMSSIIEKAREIVAVNGLADKITLLQGKMEEVQLPFPSVDIIISEWMGYFLLYESMLDTVLYAQDRYLVPGGKIFPDKATMYLAGIEDGEYKDDKIGFWDNVYGFDYSPMKEIALTEPLVDTVELKALVTDPCPIITFDLYTVTKEDLAFEVPYSLPVKRSDFVHAVIAWFDIEFGACHKPINFSTGPHAKYTHWKQTVFYLRDVLTVEEEESISGVLSNRPNDKNKRDLDINLTYKLETQDQTRFAEGGCFYRM
  
Inhibitor
Name:
BDBM50215479
Synonyms:
2-(9H-xanthen-9-ylsulfanyl)-N-{2-[2-(9H-xanthen-9-ylsulfanyl)-propionylamino]-ethyl}-propionamide | CHEMBL61824
Type:
Small organic molecule
Emp. Form.:
C34H32N2O4S2
Mol. Mass.:
596.759
SMILES:
CC(SC1c2ccccc2Oc2ccccc12)C(=O)NCCNC(=O)C(C)SC1c2ccccc2Oc2ccccc12 |w:25.28,1.0|
Structure:
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