Reaction Details Report a problem with these data
Target
Cell division protein FtsZ
Ligand
BDBM50371094
Substrate
n/a
Meas. Tech.
ChEMBL_441229 (CHEMBL891451)
IC50
2000000±n/a nM
Citation
 Paradis-Bleau, C; Beaumont, M; Sanschagrin, F; Voyer, N; Levesque, RC Parallel solid synthesis of inhibitors of the essential cell division FtsZ enzyme as a new potential class of antibacterials. Bioorg Med Chem 15:1330-40 (2007) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_PSEAE | ftsZ
Type:
PROTEIN
Mol. Mass.:
41206.43
Organism:
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228)
Description:
ChEMBL_441229
Residue:
394
Sequence:
MFELVDNIAQTAVIKVIGVGGGGGNAVNHMAKNNVEGVEFICANTDAQALKNIAARTVLQLGPGVTKGLGAGANPEVGRQAALEDRERISEVLEGADMVFITTGMGGGTGTGAAPIIAEVAKEMGILTVAVVTRPFPFEGRKRMQIADEGIRALAESVDSLITIPNEKLLTILGKDASLLAAFAKADDVLAGAVRGISDIIKRPGMINVDFADVKTVMSEMGMAMMGTGCASGPNRAREATEAAIRNPLLEDVNLQGARGILVNITAGPDLSLGEYSDVGNIIEQFASEHATVKVGTVIDADMRDELHVTVVATGLGARLEKPVKVVDNTVQGSAAQAAAPAQREQQSVNYRDLDRPTVMRNQSHGSAATAAKLNPQDDLDYLDIPAFLRRQAD
  
Inhibitor
Name:
BDBM50371094
Synonyms:
CHEMBL243380
Type:
Small organic molecule
Emp. Form.:
C16H15ClN6O3
Mol. Mass.:
374.782
SMILES:
Nc1nc(Cl)c2ncn(C[C@H](NC(=O)Cc3ccccc3)C(O)=O)c2n1
Structure:
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