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Target
Carbonic anhydrase 5A, mitochondrial
Ligand
BDBM10887
Substrate
n/a
Meas. Tech.
ChEMBL_443975 (CHEMBL893137)
Kd
25.4±n/a nM
Citation
 Vitale, RM; Pedone, C; Amodeo, P; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT; De Simone, G Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA. Bioorg Med Chem 15:4152-8 (2007) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 5A, mitochondrial
Synonyms:
CA-VA | Carbonic anhydrase 5A (CA VA) | Carbonic anhydrase 5A, mitochondrial | Carbonic anhydrase VA (CA VA) | Carbonate dehydratase VA | Carbonic anhydrase 5A, mitochondrial precursor | CAH5A_HUMAN | CA5A | CA5 | Carbonic anhydrase V | Carbonic Anhydrase VA
Type:
Enzyme
Mol. Mass.:
34755.54
Organism:
Human
Description:
Human (cloned) isozyme
Residue:
305
Sequence:
MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPLENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATNEGTRS
  
Inhibitor
Name:
BDBM10887
Synonyms:
Sulfamate 7 | [(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate | Topiramate (TPM) | US11535599, Example topiramate
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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