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Target
Beta-2 adrenergic receptor
Ligand
BDBM50221771
Substrate
n/a
Meas. Tech.
ChEMBL_446233 (CHEMBL895338)
EC50
2200±n/a nM
Citation
 Buonsanti, MF; Bertinaria, M; Stilo, AD; Cena, C; Fruttero, R; Gasco, A Nitric oxide donor beta2-agonists: furoxan derivatives containing the fenoterol moiety and related furazans. J Med Chem 50:5003-11 (2007) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2_CAVPO | Adrb2 | adrenergic Beta2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46993.24
Organism:
GUINEA PIG
Description:
adrenergic Beta2 ADRB2 GUINEA PIG::Q8K4Z4
Residue:
418
Sequence:
MGHLGNGSDFLLAPNASHAPDHNVTRERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMNMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWVVSGLTSFLPIQMHWYRATHKDAINCYAEETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAKKQLQKIDRSEGRFHTQNLSQVEQDGRSGHGLRRSSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSALKAYGNDCSSNSNGKTDYTGEPNVCHQGQEKERELLCEDPPGTEDLVSCPGTVPSDSIDSQGRNYSTNDSLL
  
Inhibitor
Name:
BDBM50221771
Synonyms:
5-(1-hydroxy-2-(1-(4-((4-methyl-1,2,5-oxadiazol-3-yl)methoxy)phenyl)propan-2-ylamino)ethyl)benzene-1,3-diol | 5-(1-hydroxy-2-{1-methyl-2-[4-(4-methyl-furazan-3-ylmethoxy)-phenyl]-ethylamino}-ethyl)-benzene-1,3-diol | CHEMBL244906
Type:
Small organic molecule
Emp. Form.:
C21H25N3O5
Mol. Mass.:
399.4403
SMILES:
CC(Cc1ccc(OCc2nonc2C)cc1)NCC(O)c1cc(O)cc(O)c1 |w:1.0,19.21|
Structure:
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