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Target
Dipeptidyl peptidase 3
Ligand
BDBM50221073
Substrate
n/a
Meas. Tech.
ChEMBL_449482 (CHEMBL899731)
IC50
>30000±n/a nM
Citation
Wright, SW; Ammirati, MJ; Andrews, KM; Brodeur, AM; Danley, DE; Doran, SD; Lillquist, JS; Liu, S; McClure, LD; McPherson, RK; Olson, TV; Orena, SJ; Parker, JC; Rocke, BN; Soeller, WC; Soglia, CB; Treadway, JL; Vanvolkenburg, MA; Zhao, Z; Cox, ED (3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization. Bioorg Med Chem Lett 17:5638-42 (2007) [PubMed] Article
More Info.:
Target
Name:
Dipeptidyl peptidase 3
Synonyms:
DPP3 | DPP3_HUMAN | Dipeptidyl arylamidase III | Dipeptidyl peptidase 3 | Dipeptidyl peptidase III | Dipeptidyl peptidase III (DPP III)
Type:
Enzyme
Mol. Mass.:
82565.94
Organism:
Homo sapiens (Human)
Description:
Q9NY33
Residue:
737
Sequence:
MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAYHLSRAAWYGGLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPKEKLERVILGSEAAQQHPEEVRGLWQTCGELMFSLEPRLRHLGLGKEGITTYFSGNCTMEDAKLAQDFLDSQNLSAYNTRLFKEVDGEGKPYYEVRLASVLGSEPSLDSEVTSKLKSYEFRGSPFQVTRGDYAPILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAEQLLKELPWPPTFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYATQREKLTFLEEDDKDLYILWKGPSFDVQVGLHELLGHGSGKLFVQDEKGAFNFDQETVINPETGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLHPQVLEIFGFEGADAEDVIYVNWLNMVRAGLLALEFYTPEAFNWRQAHMQARFVILRVLLEAGEGLVTITPTTGSDGRPDARVRLDRSKIRSVGKPALERFLRRLQVLKSTGDVAGGRALYEGYATVTDAPPECFLTLRDTVLLRKESRKLIVQPNTRLEGSDVQLLEYEASAAGLIRSFSERFPEDGPELEEILTQLATADARFWKGPSEAPSGQA
Inhibitor
Name:
BDBM50221073
Synonyms:
(3R,4S)-1-(6-(6-methoxypyridin-3-yl)pyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine | (3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE | CHEMBL237786
Type:
Small organic molecule
Emp. Form.:
C20H18F3N5O
Mol. Mass.:
401.385
SMILES:
COc1ccc(cn1)-c1cc(ncn1)N1C[C@H](N)[C@H](C1)c1cc(F)c(F)cc1F