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Target
Xaa-Pro dipeptidase
Ligand
BDBM50151843
Substrate
n/a
Meas. Tech.
ChEMBL_461055 (CHEMBL944087)
IC50
>10000±n/a nM
Citation
 Kim, D; Kowalchick, JE; Brockunier, LL; Parmee, ER; Eiermann, GJ; Fisher, MH; He, H; Leiting, B; Lyons, K; Scapin, G; Patel, SB; Petrov, A; Pryor, KD; Roy, RS; Wu, JK; Zhang, X; Wyvratt, MJ; Zhang, BB; Zhu, L; Thornberry, NA; Weber, AE Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines. J Med Chem 51:589-602 (2008) [PubMed]  Article 
Target
Name:
Xaa-Pro dipeptidase
Synonyms:
PEPD | PEPD_HUMAN | PRD
Type:
PROTEIN
Mol. Mass.:
54541.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_159887
Residue:
493
Sequence:
MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK
  
Inhibitor
Name:
BDBM50151843
Synonyms:
(R)-3-Amino-1-((R)-2-benzyl-piperazin-1-yl)-4-(2-fluoro-phenyl)-butan-1-one | (R)-3-amino-1-((R)-2-benzylpiperazin-1-yl)-4-(2-fluorophenyl)butan-1-one | 3-Amino-1-((R)-2-benzyl-piperazin-1-yl)-4-((R)-2-fluoro-phenyl)-butan-1-one | CHEMBL175872
Type:
Small organic molecule
Emp. Form.:
C21H26FN3O
Mol. Mass.:
355.449
SMILES:
N[C@@H](CC(=O)N1CCNC[C@H]1Cc1ccccc1)Cc1ccccc1F |r|
Structure:
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