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Target
Neutral cholesterol ester hydrolase 1
Ligand
BDBM50228837
Substrate
n/a
Meas. Tech.
ChEMBL_464892 (CHEMBL949091)
IC50
64000±n/a nM
Citation
 Kimball, FS; Romero, FA; Ezzili, C; Garfunkle, J; Rayl, TJ; Hochstatter, DG; Hwang, I; Boger, DL Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem 51:937-47 (2008) [PubMed]  Article 
Target
Name:
Neutral cholesterol ester hydrolase 1
Synonyms:
AADACL1 | KIAA1363 | NCEH1 | NCEH1_HUMAN
Type:
PROTEIN
Mol. Mass.:
45810.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_835312
Residue:
408
Sequence:
MRSSCVLLTALVALAAYYVYIPLPGSVSDPWKLMLLDATFRGAQQVSNLIHYLGLSHHLLALNFIIVSFGKKSAWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALASAKIRYYDELCTAMAEELNAVIVSIEYRLVPKVYFPEQIHDVVRATKYFLKPEVLQKYMVDPGRICISGDSAGGNLAAALGQQFTQDASLKNKLKLQALIYPVLQALDFNTPSYQQNVNTPILPRYVMVKYWVDYFKGNYDFVQAMIVNNHTSLDVEEAAAVRARLNWTSLLPASFTKNYKPVVQTTGNARIVQELPQLLDARSAPLIADQAVLQLLPKTYILTCEHDVLRDDGIMYAKRLESAGVEVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
  
Inhibitor
Name:
BDBM50228837
Synonyms:
2-(3-(biphenyl-4-yl)propanoyl)oxazole-5-carbonitrile | 2-(3-biphenyl-4-yl-propionyl)-oxazole-5-carbonitrile | CHEMBL272111
Type:
Small organic molecule
Emp. Form.:
C19H14N2O2
Mol. Mass.:
302.3267
SMILES:
O=C(CCc1ccc(cc1)-c1ccccc1)c1ncc(o1)C#N
Structure:
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