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Target
NF-kappa-B inhibitor alpha
Ligand
BDBM53740
Substrate
n/a
Meas. Tech.
ChEMBL_465169 (CHEMBL946815)
EC50
6800±n/a nM
Citation
 Xie, Y; Deng, S; Thomas, CJ; Liu, Y; Zhang, YQ; Rinderspacher, A; Huang, W; Gong, G; Wyler, M; Cayanis, E; Aulner, N; Többen, U; Chung, C; Pampou, S; Southall, N; Vidovic, D; Schürer, S; Branden, L; Davis, RE; Staudt, LM; Inglese, J; Austin, CP; Landry, DW; Smith, DH; Auld, DS Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation. Bioorg Med Chem Lett 18:329-35 (2008) [PubMed]  Article 
Target
Name:
NF-kappa-B inhibitor alpha
Synonyms:
I-kappa-B-alpha | IKBA | IKBA_HUMAN | MAD3 | NF-kappa-B inhibitor alpha | NFKBI | NFKBIA
Type:
GST fusion protein
Mol. Mass.:
35584.84
Organism:
Homo sapiens (Human)
Description:
It was produced in E. coli as GST-tagged fusion protein (Santa Cruz Biotechnology).
Residue:
317
Sequence:
MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL
  
Inhibitor
Name:
BDBM53740
Synonyms:
2-[(5-chloro-4-tosyl-thiazol-2-yl)amino]ethyl-dimethyl-amine | MLS000537009 | N'-{5-chloro-4-[(4-methylphenyl)sulfonyl]-1,3-thiazol-2-yl}-N,N-dimethyl-1,2-ethanediamine | N-[5-chloranyl-4-(4-methylphenyl)sulfonyl-1,3-thiazol-2-yl]-N',N'-dimethyl-ethane-1,2-diamine | N-[5-chloro-4-(4-methylphenyl)sulfonyl-1,3-thiazol-2-yl]-N',N'-dimethylethane-1,2-diamine | N-[5-chloro-4-(4-methylphenyl)sulfonyl-2-thiazolyl]-N',N'-dimethylethane-1,2-diamine | SMR000143646 | cid_1301648
Type:
Small organic molecule
Emp. Form.:
C14H18ClN3O2S2
Mol. Mass.:
359.895
SMILES:
CN(C)CCNc1nc(c(Cl)s1)S(=O)(=O)c1ccc(C)cc1
Structure:
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