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Target
Farnesyl pyrophosphate synthase
Ligand
BDBM50098378
Substrate
n/a
Meas. Tech.
ChEMBL_466620 (CHEMBL924794)
IC50
9.2±n/a nM
Citation
 Dunford, JE; Kwaasi, AA; Rogers, MJ; Barnett, BL; Ebetino, FH; Russell, RG; Oppermann, U; Kavanagh, KL Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. J Med Chem 51:2187-95 (2008) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:
Enzyme
Mol. Mass.:
48272.89
Organism:
Homo sapiens (Human)
Description:
P14324
Residue:
419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
  
Inhibitor
Name:
BDBM50098378
Synonyms:
(1-Hydroxy-1-phosphono-2-pyridin-2-yl-ethyl)-phosphonic acid | 1-hydroxy-2-(pyridin-2-yl)ethane-1,1-diyldiphosphonic acid | 2-(2-Hydroxy-2,2-bis-phosphono-ethyl)-pyridinium | 2-(2-pyridyl)-1-hydroxy-ethane-1,1-bisphosphonate | CHEMBL434024
Type:
Small organic molecule
Emp. Form.:
C7H11NO7P2
Mol. Mass.:
283.1123
SMILES:
OC(Cc1ccccn1)(P(O)(O)=O)P(O)(O)=O
Structure:
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