Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50374882
Substrate
n/a
Meas. Tech.
ChEMBL_470061 (CHEMBL933439)
Ki
10±n/a nM
Citation
 Smallheer, JM; Wang, S; Laws, ML; Nakajima, S; Hu, Z; Han, W; Jacobson, I; Luettgen, JM; Rossi, KA; Rendina, AR; Knabb, RM; Wexler, RR; Lam, PY; Quan, ML Sulfonamidolactam inhibitors of coagulation factor Xa. Bioorg Med Chem Lett 18:2428-33 (2008) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Human
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50374882
Synonyms:
CHEMBL257037
Type:
Small organic molecule
Emp. Form.:
C26H25ClFN3O4S
Mol. Mass.:
530.011
SMILES:
Fc1cc(ccc1N1CCCC(NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)N1CCCCC1=O |w:11.12|
Structure:
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