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Target
Aldo-keto reductase family 1 member C21
Ligand
BDBM15236
Substrate
n/a
Meas. Tech.
ChEMBL_470435 (CHEMBL936590)
IC50
12300±n/a nM
Citation
 Dhagat, U; Endo, S; Hara, A; El-Kabbani, O Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors. Bioorg Med Chem 16:3245-54 (2008) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member C21
Synonyms:
AK1CL_MOUSE | Akr1c21
Type:
PROTEIN
Mol. Mass.:
36879.72
Organism:
Mouse
Description:
ChEMBL_470435
Residue:
323
Sequence:
MNSKCHCVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKPGLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPVLGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRYIPAAIFKGHPNWPFLDEY
  
Inhibitor
Name:
BDBM15236
Synonyms:
CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one | cid_5281672 | 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one | Myricetin | Myricetin (20) | Myricetin (Myr)
Type:
Small organic molecule
Emp. Form.:
C15H10O8
Mol. Mass.:
318.04
SMILES:
c1c(cc(c(c1O)O)O)C2=C(C(=O)c3c(cc(cc3O2)O)O)O
Structure:
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