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Target
Casein kinase I isoform alpha
Ligand
BDBM50375645
Substrate
n/a
Meas. Tech.
ChEMBL_473616 (CHEMBL940169)
Ki
80000±n/a nM
Citation
 Fedorov, O; Marsden, B; Pogacic, V; Rellos, P; Müller, S; Bullock, AN; Schwaller, J; Sundström, M; Knapp, S A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A 104:20523-8 (2007) [PubMed]  Article 
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Homo sapiens (Human)
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
  
Inhibitor
Name:
BDBM50375645
Synonyms:
CHEMBL219301 | US11542290, Compound A-3
Type:
Small organic molecule
Emp. Form.:
C12H13ClN2O2S
Mol. Mass.:
284.762
SMILES:
NCCNS(=O)(=O)c1cccc2c(Cl)cccc12
Structure:
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