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Target
Cathepsin K
Ligand
BDBM50376510
Substrate
n/a
Meas. Tech.
ChEMBL_477021 (CHEMBL933739)
IC50
8.6±n/a nM
Citation
 Teno, N; Irie, O; Miyake, T; Gohda, K; Horiuchi, M; Tada, S; Nonomura, K; Kometani, M; Iwasaki, G; Betschart, C New chemotypes for cathepsin K inhibitors. Bioorg Med Chem Lett 18:2599-603 (2008) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50376510
Synonyms:
CHEMBL261673
Type:
Small organic molecule
Emp. Form.:
C18H19N5O
Mol. Mass.:
321.3764
SMILES:
CC(C)(C)CNc1nc(ncc1C#CCOc1cccnc1)C#N
Structure:
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