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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM50377189
Substrate
n/a
Meas. Tech.
ChEMBL_479339 (CHEMBL921622)
IC50
914±n/a nM
Citation
 Buckley, GM; Fosbeary, R; Fraser, JL; Gowers, L; Higueruelo, AP; James, LA; Jenkins, K; Mack, SR; Morgan, T; Parry, DM; Pitt, WR; Rausch, O; Richard, MD; Sabin, V IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines. Bioorg Med Chem Lett 18:3656-60 (2008) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM50377189
Synonyms:
CHEMBL255253
Type:
Small organic molecule
Emp. Form.:
C20H23N5
Mol. Mass.:
333.4301
SMILES:
CN1[C@H]2CC[C@@H]1CC(C2)Nc1cccc(n1)-c1cnc2ccccn12 |w:7.10,TEB:9:7:1:3.4|
Structure:
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