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Target
Plasmepsin II
Ligand
BDBM50377587
Substrate
n/a
Meas. Tech.
ChEMBL_479736 (CHEMBL929233)
IC50
4±n/a nM
Citation
 Azim, MK; Ahmed, W; Khan, IA; Rao, NA; Khan, KM Identification of acridinyl hydrazides as potent aspartic protease inhibitors. Bioorg Med Chem Lett 18:3011-5 (2008) [PubMed]  Article 
Target
Name:
Plasmepsin II
Synonyms:
Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:
Enzyme
Mol. Mass.:
51482.09
Organism:
Plasmodium falciparum
Description:
P46925
Residue:
453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYENVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKTNYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
  
Inhibitor
Name:
BDBM50377587
Synonyms:
CHEMBL404394
Type:
Small organic molecule
Emp. Form.:
C23H21N3O
Mol. Mass.:
355.4323
SMILES:
Cc1cccc(c1)C(=O)NNc1c2ccccc2nc2c(C)c(C)ccc12
Structure:
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