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Target
Neutral cholesterol ester hydrolase 1
Ligand
BDBM50240877
Substrate
n/a
Meas. Tech.
ChEMBL_557685 (CHEMBL962980)
IC50
10000±n/a nM
Citation
 Hoover, HS; Blankman, JL; Niessen, S; Cravatt, BF Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. Bioorg Med Chem Lett 18:5838-41 (2008) [PubMed]  Article 
Target
Name:
Neutral cholesterol ester hydrolase 1
Synonyms:
AADACL1 | KIAA1363 | NCEH1 | NCEH1_HUMAN
Type:
PROTEIN
Mol. Mass.:
45810.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_835312
Residue:
408
Sequence:
MRSSCVLLTALVALAAYYVYIPLPGSVSDPWKLMLLDATFRGAQQVSNLIHYLGLSHHLLALNFIIVSFGKKSAWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALASAKIRYYDELCTAMAEELNAVIVSIEYRLVPKVYFPEQIHDVVRATKYFLKPEVLQKYMVDPGRICISGDSAGGNLAAALGQQFTQDASLKNKLKLQALIYPVLQALDFNTPSYQQNVNTPILPRYVMVKYWVDYFKGNYDFVQAMIVNNHTSLDVEEAAAVRARLNWTSLLPASFTKNYKPVVQTTGNARIVQELPQLLDARSAPLIADQAVLQLLPKTYILTCEHDVLRDDGIMYAKRLESAGVEVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
  
Inhibitor
Name:
BDBM50240877
Synonyms:
CHEMBL158897 | Quinolyl derivatives | cyclohexanone O-6-((cyclohexylideneaminooxy)carbonylamino)hexylcarbamoyl oxime
Type:
Small organic molecule
Emp. Form.:
C20H34N4O4
Mol. Mass.:
394.5084
SMILES:
O=[#6](-[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#8]\[#7]=[#6]-1\[#6]-[#6]-[#6]-[#6]-[#6]-1)-[#8]\[#7]=[#6]-1\[#6]-[#6]-[#6]-[#6]-[#6]-1
Structure:
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