Reaction Details Report a problem with these data
Target
Beta-ketoacyl-[acyl-carrier-protein] synthase III
Ligand
BDBM50245878
Substrate
n/a
Meas. Tech.
ChEMBL_559689 (CHEMBL1010087)
IC50
29.6±n/a nM
Citation
 Alhamadsheh, MM; Waters, NC; Sachdeva, S; Lee, P; Reynolds, KA Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett 18:6402-5 (2008) [PubMed]  Article 
Target
Name:
Beta-ketoacyl-[acyl-carrier-protein] synthase III
Synonyms:
Beta-ketoacyl-ACP-synthase III
Type:
PROTEIN
Mol. Mass.:
42334.64
Organism:
Plasmodium falciparum
Description:
ChEMBL_559689
Residue:
371
Sequence:
MFLYFITYLCIFHNNIYSVELIKNNKYNFINNVHNIKYRTKIRAIYGKTGGKIIGHGHSYPSTEIYNDELKKYVDTNDEWIRTRTGIKKRRILKRDENISMLQIDSATQALETSCLKPSDIDMVINASSTPQNLFGDANNISNKIGCKNSVNMDLTAACTGFIFAFVTAYNFLNRYKNILIVGSDALSNFVDWRDRNTCVLFGDAAGAVVLQRTEEKEENKIFNYYLGSDSELNDLLTINFDHDKYNLDKPNVNKYGKLYMNGKEVFKYTISNIPKILKKAIQHSNINIEDINYFIFHQANIRIIETVAKNLNIPMSKVLVNLDEYANTSAASIPLCFSENIKNGKIKTNDIICMCGFGAGMSYGCVILKY
  
Inhibitor
Name:
BDBM50245878
Synonyms:
CHEMBL512926 | N-(4-(1,4-dihydroxynaphthalen-2-ylsulfonyl)phenyl)acetamide
Type:
Small organic molecule
Emp. Form.:
C18H15NO5S
Mol. Mass.:
357.38
SMILES:
CC(=O)Nc1ccc(cc1)S(=O)(=O)c1cc(O)c2ccccc2c1O
Structure:
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