Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50377975
Substrate
n/a
Meas. Tech.
ChEMBL_539205 (CHEMBL1024709)
IC50
17000±n/a nM
Citation
 Long, YQ; Xue, T; Song, YL; Liu, ZL; Huang, SX; Yu, Q Synthesis and utilization of chiral alpha-methylated alpha-amino acids with a carboxyalkyl side chain in the design of novel Grb2-SH2 peptide inhibitors free of phosphotyrosine. J Med Chem 51:6371-80 (2008) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50377975
Synonyms:
CHEMBL1627245
Type:
Small organic molecule
Emp. Form.:
C42H63N9O15S
Mol. Mass.:
966.066
SMILES:
CC(C)C[C@@H]1NC(=O)[C@H](CCCC(O)=O)NC(=O)C[S@@](=O)C[C@H](NC(=O)CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@](C)(CCCC(O)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(N)=O |r|
Structure:
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