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Target
ATP-binding cassette sub-family C member 9
Ligand
BDBM50240750
Substrate
n/a
Meas. Tech.
ChEMBL_495672 (CHEMBL1006149)
EC50
3540±n/a nM
Citation
 Zhang, X; Qiu, Y; Li, X; Bhattacharjee, S; Woods, M; Kraft, P; Lundeen, SG; Sui, Z Discovery and structure-activity relationships of a novel series of benzopyran-based K(ATP) openers for urge urinary incontinence. Bioorg Med Chem 17:855-66 (2009) [PubMed]  Article 
Target
Name:
ATP-binding cassette sub-family C member 9
Synonyms:
ABCC9 | ABCC9_HUMAN | ATP-binding cassette transporter sub-family C member 9 | SUR2 | Sulfonylurea receptor 2 | Sulfonylurea receptor 2, Kir6.2
Type:
PROTEIN
Mol. Mass.:
174236.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_495672
Residue:
1549
Sequence:
MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK
  
Inhibitor
Name:
BDBM50240750
Synonyms:
()-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine | (+/-)-Pinacidil | 4N-cyanoimino(1,2,2-trimethylpropylamino)methyl-4-pyridinamine(Pinacidil) | 4N-cyanoimino[1,2,2-trimethyl-(1R)-propylamino]methyl-4-pyridinamine | 4N-cyanoimino[1,2,2-trimethyl-(1S)-propylamino]methyl-4-pyridinamine | CHEMBL1159 | N''-cyano-N-pyridin-4-yl-N'-(1,2,2-trimethylpropyl)guanidine | N''-cyano-N-pyridin-4-yl-N'-(1,2,2-trimethylpropyl)guanidine ((+)-pinacidil) | N''-cyano-N-pyridin-4-yl-N'-(1,2,2-trimethylpropyl)guanidine (Pinacidil) | N''-cyano-N-pyridin-4-yl-N'-[(1R)-1,2,2-trimethylpropyl]guanidine | N''-cyano-N-pyridin-4-yl-N'-[(1S)-1,2,2-trimethylpropyl]guanidine | N-Pyridin-4-yl-N'-(1,2,2-trimethyl-propyl)-cyanoguanidine (pinacidil) | PINACIDIL
Type:
Small organic molecule
Emp. Form.:
C13H19N5
Mol. Mass.:
245.3235
SMILES:
CC(NC(NC#N)=Nc1ccncc1)C(C)(C)C |w:7.7|
Structure:
Search PDB for entries with ligand similarity: