Reaction Details Report a problem with these data
Target
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
Ligand
BDBM12342
Substrate
n/a
Meas. Tech.
ChEMBL_543345 (CHEMBL1023015)
IC50
691830±n/a nM
Citation
 Freitas, RF; Prokopczyk, IM; Zottis, A; Oliva, G; Andricopulo, AD; Trevisan, MT; Vilegas, W; Silva, MG; Montanari, CA Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors. Bioorg Med Chem 17:2476-82 (2009) [PubMed]  Article 
Target
Name:
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
Synonyms:
G3PG_TRYCR
Type:
PROTEIN
Mol. Mass.:
39070.68
Organism:
Trypanosoma cruzi
Description:
ChEMBL_973242
Residue:
359
Sequence:
MPIKVGINGFGRIGRMVFQALCEDGLLGTEIDVVAVVDMNTDAEYFAYQMRYDTVHGKFKYEVTTTKSSPSVAKDDTLVVNGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTAKAAAEGHLRGGARKVVISAPASGGAKTLVMGVNHHEYNPSEHHVVSNASCTTNCLAPIVHVLVKEGFGVQTGLMTTIHSYTATQKTVDGVSVKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTQGKLTGMSFRVPTPDVSVVDLTFTAARDTSIQEIDAALKRASKTYMKGILGYTDEELVSADFINDNRSSIYDSKATLQNNLPKERRFFKIVSWYDNEWGYSHRVVDLVRHMASKDRSARL
  
Inhibitor
Name:
BDBM12342
Synonyms:
2H-chromen-2-one | CHEMBL6466 | Coumarin
Type:
Natural product
Emp. Form.:
C9H6O2
Mol. Mass.:
146.1427
SMILES:
O=c1ccc2ccccc2o1
Structure:
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